Researchers Grow 3-D Human Brain Tissues
Scientists at the Institute of Molecular Biotechnology in Vienna, Austria, have grown three-dimensional human brain tissues from stem cells. The tissues form discrete structures that are seen in the developing brain.
The Vienna researchers found that immature brain cells derived from stem cells self-organize into brain-like tissues in the right culture conditions. The “cerebral organoids,” as the researchers call them, grew to about four millimeters in size and could survive as long as 10 months. For decades, scientists have been able to take cells from animals including humans and grow them in a petri dish, but for the most part this has been done in two dimensions, with the cells grown in a thin layer in petri dishes. But in recent years, researchers have advanced tissue culture techniques so that three-dimensional brain tissue can grow in the lab. The new report from the Austrian team demonstrates that allowing immature brain cells to self-organize yields some of the largest and most complex lab-grown brain tissue, with distinct subregions and signs of functional neurons.